SRILS Teams Reveal Mechanism of m⁶A Regulating LTR Silencing and Restricting Human ESC Totipotency

Stem cell totipotency is a critical state in early development. This research reveals a cross-hierarchical transcriptional regulatory network where m⁶A modification plays a pivotal role.

By analyzing L1PA elements and LTR sequences, the researchers found that specific RNA modifications act as a 'gatekeeper' to prevent human embryonic stem cells from regressing into a more primitive totipotent state, thus ensuring normal developmental progression.